Therapeutic Effects of the Superoxide Dismutase Mimetic Compound Mn^IIMe₂DO2A on Experimental Articular Pain in Rats

Figure 2

Effect of MnL4, H₂L4, ibuprofen, and diclofenac on complete Freund’s adjuvant-induced inflammatory arthritis. Complete Freund’s adjuvant (CFA, 50 μL) was injected in the left posterior tibiotarsal articulation 7 days before the pain evaluation by the paw pressure test. Molecules or saline was administered i.p. at the indicated doses at time 0 and measures were performed at time 15, 30, 45, and 60 min. Values are the mean ± s.e.m. of 6 animals. *𝑃<0.05 and **𝑃<0.01 versus the ipsilateral paw of CFA + saline group.