Therapeutic Effects of the Superoxide Dismutase Mimetic Compound Me2DO2A on Experimental Articular Pain in Rats
Figure 4
Effect of MnL4 (continuously infused for 15 days) on monoiodoacetate- (MIA-) induced unilateral osteoarthritis. MIA (2 mg/25 μL) was injected in the left posterior tibiotarsal articulation 14 days before the pain evaluation by the paw pressure test. At day 0, a minipump containing MnL4 solution (15 mg kg−1 day) was implanted on the back of MnL4-treated rats. Values are the mean ± s.e.m. of 5 animals. Panel (a): pain behavior; * and ** versus MIA + saline. Panel (b): effect of MnL4 (continuously infused for 15 days) on tibiotarsal articulation histopathology on MIA-induced osteoarthritis. Hematoxilin and eosin staining of longitudinal section of tibiotarsal joint. Pictures are representative of histological preparations from 5 animals per group. Bars = 100 μm.
