Pathogenesis of the Metabolic Syndrome: Insights from Monogenic Disorders

<table>Location of common monogenic pancreatic beta cell defects leading to early onset of diabetes in absence of obesity-related insulin resistance.  Hepatocyte nuclear factor (HNF), potassium adenosine triphosphate (KATP) channel, sulphonylurea receptor (SUR).</table>

Mediators of Inflammation

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Figure 2

Figure 2: Pathogenesis of the Metabolic Syndrome: Insights from Monogenic Disorders 