Review Article
Matrix Metalloproteinases: Inflammatory Regulators of Cell Behaviors in Vascular Formation and Remodeling
Table 1
MMPs, stem/progenitor cell mobilization and recruitment, and angiogenesis.
| MMPs | Stem/progenitor cells | Functions/effects | Substrates | Outcomes | References |
| MT1-MMP | BMSCs | Migration/invasion↑ | ECM (fibrin) | Angiogenesis | [68, 69] |
| MMP-9 | BM-EPCs/BM-HSCs (c-kit+) | Adhesion/migration↑ | c-kit ligand | Neovascularization | [70, 71] | BM-myelomonocytic cells (CD11b+) | Recruitment/invasion↑ | ECM | Tumor vasculogenesis | [72] | BMSCs (CD34+) | Migration/invasion↑ | ECM | Restenosis | [73, 74] |
| MMP-2 | BM-EPCs (c-kit+) | Invasion/proliferation↑ | ECM VEGF signaling | Neovascularization | [75] |
| MMP-8 | SPC (CD34+/c-kit+/Sca-1+/ Flk-1+) | Recruitment/migration↑ | ECM ADAM10 | Atherosclerosis | [76] |
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