Matrix Metalloproteinases: Inflammatory Regulators of Cell Behaviors in Vascular Formation and Remodeling

Table 1

MMPs, stem/progenitor cell mobilization and recruitment, and angiogenesis.

MMPs	Stem/progenitor cells	Functions/effects	Substrates	Outcomes	References
MT1-MMP	BMSCs	Migration/invasion↑	ECM (fibrin)	Angiogenesis	[68, 69]
MMP-9	BM-EPCs/BM-HSCs (c-kit+)	Adhesion/migration↑	c-kit ligand	Neovascularization	[70, 71]
	BM-myelomonocytic cells (CD11b+)	Recruitment/invasion↑	ECM	Tumor vasculogenesis	[72]
	BMSCs (CD34+)	Migration/invasion↑	ECM	Restenosis	[73, 74]
MMP-2	BM-EPCs (c-kit+)	Invasion/proliferation↑	ECM; VEGF signaling	Neovascularization	[75]
MMP-8	SPC (CD34+/c-kit+/Sca-1+/; Flk-1+)	Recruitment/migration↑	ECM; ADAM10	Atherosclerosis	[76]