Review Article
Matrix Metalloproteinases: Inflammatory Regulators of Cell Behaviors in Vascular Formation and Remodeling
Table 2
MMPs and vascular EC function in angiogenesis.
| MMPs | Functions/effects | Substrates/signaling pathway | Outcomes | References |
| MMP-1 | Proliferation↑ | PAR-1/NF-κB→VEGFR2 | Angiogenesis Vascular remodeling | [77, 78] | MMP-8 | Proliferation/migration↑ | Ang I→PECAM-1→β-catenin | Angiogenesis | [79] | MT1-MMP | Migration/invasion↑ | ECM (collagen) | Vascular formation | [80–83] | MMP-9 | Migration/invasion↑ | ECM | Angiogenesis | [84] | MMP-2 | Survival/apoptosis↑ | Caspases and p38 MAPK | Angiogenesis Angioregression | [59, 85] | MMP-12 | Proliferation/migration↑ | uPAR | Systemic sclerosis | [86–88] | MMP-7 | Proliferation/migration↑ | Soluble VEGFR-1 | Angiogenesis | [89, 90] |
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