Mediators of Inflammation

Review Article

Visfatin/Nampt: An Adipokine with Cardiovascular Impact

Table 1

Summary of the main correlations reported between visfatin circulating levels and CV disease in human subjects.


Clinical condition	Main correlations found	References

TD2	+Endothelial dysfunction (FMD)	[32]
TD2	+Homocystein, ±ADMA	[33]
TD2	+Carotid IMT	[35]
Morbid obesity	+Epicardial fat thickness, +PAI-1	[36]
Preeclampsia	+CRP, +IL-6, +blood pressure, and +free fatty acids	[37]
Metabolic syndrome	+IL-6, +MCP-1, and +IMT	[38]
Metabolic syndrome	+Blood pressure	[29]
PCOS	+Endothelial dysfunction (FMD), ±hsCRP, and ±IMT	[39]
CAD	+MCP-1, +IL-6	[40]
CKD	−GFR, +TD2, and +endothelial dysfunction (FMD)	[41]
CKD	+GFR, +IL-6, +CRP, and +sVCAM-1	[42]
CKD	+sVCAM-1, +sICAM-1, and +MCAM	[43, 44]
Hemodialysis	±Atherosclerosis, +hsCRP	[45]
Renal transplantation	+Endothelial function (FMD)	[46]
Ischemic stroke	+hsCRP, −LDLc	[47]
STEMI	+Occlusion IRA, +hsCRP, and +myocardial damage	[48, 49]

: no change in circulating visfatin levels. : enhanced circulating visfatin levels. : reduced circulating visfatin levels. +: positive correlation reported, −: negative correlation reported, ±: no significant correlation reported. CAD: coronary artery disease, FMD: flow-mediated dilation, GFR: glomerular filtration rate, hsCRP: high-sensitivity C-reactive protein, IL: interleukin, IMT: intima-media thickness, IRA: infarct-related artery, LDLc: low-density lipoprotein-associated cholesterol, MCAM: melanoma cell adhesion molecule, MCP-1: monocyte chemotactic protein-1, PAI-1: plasminogen activator inhibitor-1, PCOS: polycystic ovary syndrome, sICAM: soluble intercellular adhesion molecule, sVCAM: soluble vascular cell adhesion molecule, and TD2: type 2 diabetes mellitus.