Celecoxib Improves Host Defense through Prostaglandin Inhibition during Histoplasma capsulatum Infection
Figure 4
The inhibition of endogenous prostaglandin synthesis alters BALF leukocyte numbers during H. capsulatum infection. BALF cells were obtained from mice after i.t. injection of PBS or sublethal H. capsulatum infection and daily p.o. administration of water or celecoxib (1 mg/kg/0.5 mL). (a) Neutrophils and (b) mononuclear cells. The cells were enumerated and identified after cytospin preparation and panoptic staining. The data are presented as the means ± SEM representative of three independent experiments . One-way ANOVA (Tukey's multiple comparison test) was used. *PBS + H2O versus Hc + H2O or versus Hc + celecoxib; #Hc + H2O versus Hc + celecoxib .
