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Mediators of Inflammation
Volume 2013, Article ID 969875, 9 pages
http://dx.doi.org/10.1155/2013/969875
Clinical Study

Diagnostic Value of Dynamics Serum sCD163, sTREM-1, PCT, and CRP in Differentiating Sepsis, Severity Assessment, and Prognostic Prediction

1Department of Respiratory Medicine, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China
2Medical College, Nankai University, Tianjin 300071, China
3Nanlou Respiratory Disease Department, Chinese PLA General Hospital, Beijing 100853, China
4Department of Respiratory Medicine, Guangzhou Women and Children Medical Care Center, Guangzhou, Guangdong 510623, China
5Department of Critical Care Medicine, Chinese PLA General Hospital, Beijing 100853, China
6Department of Medical Statistics, Chinese PLA General Hospital, Beijing 100853, China

Received 24 September 2012; Accepted 22 May 2013

Academic Editor: Celeste C. Finnerty

Copyright © 2013 Longxiang Su et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To describe the dynamics changes of sCD163, soluble serum triggering receptor expressed on myeloid cells-1 (sTREM-1), procalcitonin (PCT), and C-reactive protein (CRP) during the course of sepsis, as well as their outcome prediction. Patients and Methods. An SIRS group (30 cases) and a sepsis group (100 cases) were involved in this study. Based on a 28-day survival, the sepsis was further divided into the survivors’ and nonsurvivors’ groups. Serum sTREM-1, sCD163, PCT, CRP, and WBC counts were tested on days 1, 3, 5, 7, 10, and 14. Results. On the ICU admission, the sepsis group displayed higher levels of sTREM-1, sCD163, PCT, and CRP than the SIRS group ( ). Although PCT and sTREM-1 are good markers to identify severity, sTREM-1 is more reliable, which proved to be a risk factor related to sepsis. During a 14-day observation, sCD163, sTREM-1, PCT, and SOFA scores continued to climb among nonsurvivors, while their WBC and CRP went down. Both sCD163 and SOFA scores are risk factors impacting the survival time. Conclusion. With regard to sepsis diagnosis and severity, sTREM-1 is more ideal and constitutes a risk factor. sCD163 is of a positive value in dynamic prognostic assessment and may be taken as a survival-impacting risk factor.