Table 3: Utility of host markers detected in saliva in the diagnosis of TB disease.

MarkerTB diseaseNo TB disease valueAUC (95% CI)Cut-off valueSensitivity % (95% CI)Specificity % (95% CI)

IL-637.3 (0.0–52.2)0.0 (0.0–13.2)0.0190.72 (0.54–0.91)>25.863.6 (30.8–89.0)81.5 (61.9–93.7)
CRP246.5 (22.0–353.9)45.9 (0.0–122.0)0.0240.74 (0.53–0.94)>271.745.5 (16.8–76.6)92.6 (75.7–99.0)
IL-90.0 (0.0–11.0)0.0 (0.0-0.0)0.0270.65 (0.44–0.86)>10.327.3 (6.0–60.9)96.3 (81.0–99.9)
IL-50.9 (0.0–9.2)0.0 (0.0-0.0)0.0330.68 (0.48–0.88)>7.827.3 (6.0–61.0)96.3 (81.0–99.9)
MIP-1 17.0 (11.3–22.2)11.3 (8.4–15.6)0.0390.72 (0.54–0.90)>18.745.5 (16.8–76.6)92.6 (75.7–99.1)
Fractalkine772.9 (225.8–1148.3)338.2 (104.3–565.5)0.0410.72 (0.52–0.91)>912.236.4 (10.9–69.2)96.3 (81.0–99.9)
IL-1718.9 (7.6–37.0)12.6 (8.6–16.6)0.0850.68 (0.46–0.90)>29.045.5 (16.8–76.6)96.3 (81.0–99.9)
VEGF457.3 (307.7–754.9)680.0 (512.4–802.6)0.0850.68 (0.47–0.90)<370.545.5 (16.8–76.6)92.6 (75.7–99.1)

Median levels and interquartile ranges (in parenthesis) of the markers and abilities to discriminate between pulmonary TB cases ( ) and individuals without active TB ( ) are shown. Only markers for which Mann-Whitney    values were ≤0.09 are shown. AUC: area under the receiver operator characteristics (ROC) curve; 95% CI: 95% confidence interval. The cut-off values are for sensitivity and specificity for TB disease and were selected based on the highest likelihood ratio. Marker levels are in pg/mL except for CRP (ng/mL).