Poly--Glutamic Acid Attenuates Angiogenesis and Inflammation in Experimental Colitis
Figure 1
γ-PGA attenuates clinical signs in mice with DSS-induced colitis. (a) Changes in the body weights and (b) clinical scores of γ-PGA-treated mice and control mice administered 3% DSS were monitored every day. Body weight values are expressed as a percentage of body weight on day 0. (c) Colons were obtained from mice 7 days after commencement of DSS administration, and their lengths were measured. (d) Macroscopic features of the colons. Control group (without DSS; Cont), 3% DSS administration group (DSS), 3% DSS with γ-PGA at 50 mg/kg body weight per day (D + P50), 3% DSS with γ-PGA at 200 mg/kg body weight per day (D + P200). Data shown are from 3 independent experiments and are expressed as mean ± SD ( per group). *, DSS versus Cont; #, D + P50 and D + P200 versus DSS.
