Diethylcarbamazine Attenuates the Development of Carrageenan-Induced Lung Injury in Mice
Figure 9
Effect of DEC on carrageenan-induced TNF-α and NO production in the lung. (a) TNF-α levels were significantly elevated 4 h after carrageenan administration in the CAR group in comparison to the sham group. DEC significantly reduced the TNF-α level, but INDO did not reduce TNF-α level in comparison to the CAR group. Nitrite and nitrate levels, stable NO metabolites, were significantly increased in the pleural exudates 4 h after carrageenan administration in comparison to the sham group. DEC and INDO significantly reduced the nitrite and nitrate level in the exudates (b). Data expressed as mean ± S.E.M. from mice for each group; versus carrageenan.
