The Beta-2-Adrenoreceptor Agonists, Formoterol and Indacaterol, but Not Salbutamol, Effectively Suppress the Reactivity of Human Neutrophils In Vitro

Figure 3

Effects of formoterol, indacaterol, and salbutamol (1–1000 nM) on the release of elastase from neutrophils activated with N-formyl-L-methionyl-L-leucyl-L-phenylalanine (1 μM)/cytochalasin B (1 μM) (fMLP/CB). The results of 3 separate experiments (𝑛=3) with 5 replicates for each drug concentration and control system in each experiment are expressed as the mean percentage of control ± SEM. The absolute values for the unstimulated control system and for cells activated with fMLP/CB were 47±6 and 1551±78 milliunits elastase per 10⁷ cells. ^∗𝑃<0.0102–0.0001 for comparison with the drug-free control systems.