The Beta-2-Adrenoreceptor Agonists, Formoterol and Indacaterol, but Not Salbutamol, Effectively Suppress the Reactivity of Human Neutrophils In Vitro

Figure 4

Effects of formoterol, indacaterol, and salbutamol (10 and 100 nM) on the production of LTB₄ by fMLP- (a) and PAF- (b) activated neutrophils. The results of 5 separate experiments (𝑛=5) with 2 replicates for each drug concentration and control system in each experiment are expressed as the mean percentage of control ± SEM. The absolute values for the unstimulated control system and for cells activated with either fMLP or PAF were 33±7, 1095.4±362.2, and 1546±1108.5 pg mL⁻¹. ^∗𝑃<0.001 for comparison with the drug-free control systems.

(a)

(b)