The Beta-2-Adrenoreceptor Agonists, Formoterol and Indacaterol, but Not Salbutamol, Effectively Suppress the Reactivity of Human Neutrophils In Vitro

Table 1

Effects of formoterol, indacaterol, and salbutamol (1, 10, 100, and 1000 nM) on the cytosolic Ca²⁺ concentrations (area under curve) of FMLP- and PAF-activated neutrophils.

Agent	FMLP; Mean ± SEM (cm^2)	PAF; Mean ± SEM (cm^2)
Control (DMSO)	8.6 ± 0.64	13.8 ± 0.53
Formoterol 1 nM	ND	10.9 ± 0.90
Indacaterol 1 nM	ND	12.2 ± 1.34
Salbutamol 1 nM	ND	14.3 ± 1.20
Formoterol 10 nM	4.8 ± 0.64*	10.9 ± 0.74*
Indacaterol 10 nM	5.6 ± 0.56*	10.9 ± 1.08*
Salbutamol 10 nM	7.3 ± 0.50	13.6 ± 1.25
Formoterol 100 nM	4.5 ± 0.28*	9.8 ± 0.90*
Indacaterol 100 nM	5.1 ± 0.57*	10.7 ± 0.90*
Salbutamol 100 nM	7.7 ± 0.74	12.8 ± 1.40
Formoterol 1000 nM	ND	8.0 ± 0.74*
Indacaterol 1000 nM	ND	8.4 ± 0.90*
Salbutamol 1000 nM	ND	10.3 ± 1.90

ND: not done.
^∗𝑃 = 0.02–0.0003.