The Beta-2-Adrenoreceptor Agonists, Formoterol and Indacaterol, but Not Salbutamol, Effectively Suppress the Reactivity of Human Neutrophils In Vitro

Table 2

Effects of formoterol, indacaterol, and salbutamol on Mn²⁺ quenching of fura-2 fluorescence in FMLP- and PAF-activated neutrophils.

Agent	FMLP-activated neutrophils		PAF-activated neutrophils
	Magnitude of decrement at 1 minute (cm); Mean ± SEM	Magnitude of decrement at 4 minutes (cm); Mean ± SEM	Magnitude of decrement at 1 minute (cm); Mean ± SEM	Magnitude of decrement at 4 minutes (cm); Mean ± SEM
Control (DMSO)	1.40 ± 0.09	5.40 ± 0.30	2.7 ± 0.15	7.4 ± 0.67
Formoterol 100 nM	1.24 ± 0.09	3.70 ± 0.13*	2.5 ± 0.16	5.1 ± 0.55*
Indacaterol 100 nM	1.30 ± 0.07	3.74 ± 0.19*	2.4 ± 0.17	5.2 ± 0.50
Salbutamol 100 nM	1.60 ± 0.09	5.30 ± 0.22	2.7 ± 0.17	6.8 ± 0.73

^∗𝑃 = 0.04–0.009.