A Novel Rose Hip Preparation with Enhanced Anti-Inflammatory and Chondroprotective Effects
Table 2
Secretion of proteins by activated PBL. LPS/IFN--stimulated cells were cultured with 125–500 μg/mL RHP for 24 h and proteins were quantified by multiparametric analysis. Only values for (LPS/IFN--stimulated) cells and (500 μg/mL RHP + LPS/IFN--stimulated) cells are given. Differences between RH-A and RH-B are given in the right-side column.
Protein
LPS/IFN-
LPS/IFN- + RH-A (500 μg/mL)
LPS/IFN- + RH-B (500 μg/mL)
RH-A versus RH-B
pg/mL ± stdev
pg/mL ± stdev
valuea
pg/mL ± stdev
value
CCL11/Eotaxin
194 ± 7
150 ± 16
0.069
141 ± 15
0.045
NSb
CCL2/MCP-1
1136 ± 126
1513 ± 145
0.109
837 ± 106
0.123
0.042
CCL3/MIP-1
4028 ± 513
13050 ± 919
0.007
5455 ± 495
0.105
0.010
CCL4/MIP-1
35500 ± 1697
93875 ± 1167
0.095
25800 ± 7354
0.211
0.009
CXCL8/IL-8
30600 ± 3253
233250 ± 61165
0.042
155125 ± 74635
0.142
NS
CCL5/RANTES
11188 ± 1962
545 ± 91
0.017
353 ± 54
0.016
NS
CXCL10/IP-10
37075 ± 11208
266 ± 27
0.043
228 ± 35
0.043
NS
IL-1
7165 ± 1520
37800 ± 1980
0.003
18550 ± 1697
0.019
0.021
IL-6
59975 ± 10006
47000 ± 6293
0.261
6525 ± 92
0.017
0.003
IL-12 (p70)
134 ± 17
31 ± 5
0.015
25 ± 7
0.015
NS
IL-10
778 ± 84
845 ± 73
0.487
179 ± 16
0.010
0.010
TNF-
10515 ± 474
27325 ± 3712
0.024
6745 ± 983
0.039
0.044
GM-CSF
113 ± 10
212 ± 17
0.018
158 ± 8
0.040
NS
G-CSF
831 ± 165
14075 ± 2510
0.018
1272 ± 16
0.064
0.005
value: significance value between (LPS/IFN-) and (LPS/IFN- + substance) treatment.
bNS: not significant.
