An Asp49 Phospholipase A2 from Snake Venom Induces Cyclooxygenase-2 Expression and Prostaglandin E2 Production via Activation of NF-κB, p38MAPK, and PKC in Macrophages
Figure 1
MT-III activates NF-B in macrophages in culture. (a, c) Macrophages nuclear extracts were prepared and assayed for B probe activity with 32P-labeled double-stranded oligonucleotide B by EMSA. (b, d) Densitometric analysis of NF-B band intensities. Results are expressed as mean ± SEM from three experiments. * as compared with control value. NS: nonspecific band; C: control; NC: negative control.
