Interleukin-17 Gene Polymorphisms Contribute to Cancer Risk

Table 1

Characteristics of case-control studies on IL-17A rs2275913G>A and IL-17F rs763780 T>C polymorphisms and cancer risk included in the meta-analysis.

First author	Year	Country	Ethnicity	Source of controls	Case	Control	Genotype distribution						P for HWE^a	MAF	Genotyping method	Cancer category
							Case			Control
							G/G	G/A	A/A	G/G	G/A	A/A
Zhang [20]	2014	China	Asian	Population controls	260	512	110	102	48	258	187	67	<0.01	0.31	MassARRAY	Gastric cancer
Zhou [21]	2013	China	Asian	Hospital controls	301	446	79	154	68	164	204	78	0.29	0.40	TaqMan	Bladder cancer
Zhu [22]	2014	China	Asian	Hospital controls	293	550	126	122	45	273	216	61	0.07	0.31	MassARRAY	Gastric cancer
Rafiei [23]	2013	Iran	Caucasian	Healthy controls	161	171	56	61	44	78	72	21	0.49	0.33	PCR-RFLP	Gastric cancer
Quan [24]	2012	China	Asian	Hospital controls	311	463	93	142	76	168	215	80	0.43	0.40	TaqMan	Cervical cancer
Arisawa [25]	2012	Japan	Asian	Hospital controls	333	583	112	137	84	218	293	72	0.08	0.37	PCR-SSCP	Gastric cancer
Wang [26]	2012	China	Asian	Population controls	491	501	165	234	92	198	245	58	0.17	0.36	SNaPshot SNP assay	Breast cancer
Wu [27]	2010	China	Asian	Population controls	945	768	210	485	250	193	371	204	0.35	0.51	PCR-RFLP	Gastric cancer
Chen [28]	2010	China	Asian	Population controls	1042	1090	300	522	220	325	541	224	0.97	0.45	TaqMan	Gastric cancer
Shibata [15]	2009	Japan	Asian	Hospital controls	287	523	94	124	69	175	299	49	<0.01	0.38	PCR-SSCP	Gastric cancer
							T/T	T/C	C/C	T/T	T/C	C/C
Zhang [20]	2014	China	Asian	Population controls	260	512	209	30	21	429	53	30	<0.01	0.11	MassARRAY	Gastric cancer
Zhou [21]	2013	China	Asian	Hospital controls	301	446	240	57	4	317	124	5	0.06	0.15	TaqMan	Bladder cancer
Zhu [22]	2014	China	Asian	Hospital controls	293	550	241	35	17	463	58	29	<0.01	0.11	MassARRAY	Gastric cancer
Quan [24]	2012	China	Asian	Hospital controls	311	462	222	85	4	332	126	5	0.06	0.15	TaqMan	Cervical cancer
Wang [26]	2012	China	Asian	Population controls	491	502	382	103	6	396	99	7	0.77	0.11	SNaPshot SNP assay	Breast cancer
Wu [27]	2010	China	Asian	Population controls	927	777	540	332	55	527	214	36	0.02	0.18	PCR-RFLP	Gastric cancer
Shibata [15]	2009	Japan	Asian	Hospital controls	280	523	221	55	4	419	100	4	0.46	0.10	PCR-SSCP	Gastric cancer

aHWE in control.
MAF: minor allele frequency in control group.