Interleukin-17 Gene Polymorphisms Contribute to Cancer Risk

Table 2

Summary of ORs and 95% CI of IL-17A rs2275913G>A and IL-17F rs763780T>C polymorphisms and cancer risk.

	N *	A versus G				GA versus GG				AA versus GG				GA + AA versus GG				AA versus GG + GA
		OR	95% CI	P	𝐼^2 (%)^a	OR	95% CI	P	𝐼^2 (%)^a	OR	95% CI	P	𝐼^2 (%)^a	OR	95% CI	P	𝐼^2 (%)^a	OR	95% CI	P	𝐼^2 (%)^a
Total	10	1.28	1.16–1.41	<0.001	61.1	1.12	1.02–1.23	0.015	27.8	1.71	1.38–2.14	<0.001	69.6	1.23	1.13–1.34	<0.001	6.4	1.62	1.27–2.07	<0.001	81.4
HWE	8	1.26	1.13–1.41	<0.001	66.4	1.15	1.04–1.27	0.008	0	1.63	1.29–2.08	<0.001	70	1.23	1.12–1.36	<0.001	9.7	1.51	1.18–1.93	0.001	78.4
Ethnicity
Asian	9	1.25	1.14–1.37	<0.001	56.5	1.12	1.02–1.23	0.019	35.6	1.65	1.32–2.05	<0.001	68.6	1.22	1.12–1.33	<0.001	4.4	1.55	1.21–1.99	0.001	81.6
China	7	1.21	1.10–1.34	<0.001	56.2	1.19	1.07–1.32	0.001	0	1.46	1.20–1.79	<0.001	54.3	1.24	1.13–1.37	<0.001	14.9	1.30	1.09–1.56	0.004	56.6
Design
PB	4	1.16	1.01–1.32	0.031	63.3	1.14	1.01–1.29	0.041	0	1.34	1.02–1.76	0.033	65	1.18	1.05–1.32	0.006	1.1	1.23	0.96–1.59	0.108	69.7
HB	5	1.35	1.23–1.48	<0.001	0	1.10	0.87–1.39	0.447	63.1	1.97	1.64–2.37	<0.001	0	1.28	1.12–1.46	<0.001	11.8	1.87	1.38–2.52	<0.001	69.2
Location
Gastric	7	1.26	1.11–1.44	<0.001	70	1.07	0.96–1.19	0.202	24.2	1.70	1.26–2.30	0.001	77.8	1.18	1.06–1.30	0.001	0	1.67	1.18–2.36	0.004	87
Others	3	1.33	1.19–1.49	<0.001	0	1.27	1.05–1.53	0.013	6.6	1.81	1.43–2.29	<0.001	0	1.39	1.18–1.65	<0.001	0	1.56	1.27–1.91	<0.001	0
		C versus T				TC versus TT				CC versus TT				TC + CC versus TT				CC versus TT + TC
Total	7	1.09	0.91–1.30	0.347	64.6	1.06	0.84–1.34	0.629	70	1.33	1.02–1.75	0.038	0	1.08	0.87–1.35	0.486	70.3	1.26	0.96–1.65	0.098	0
HWE	4	0.95	0.81–1.10	0.516	46.4	0.92	0.71–1.19	0.650	57.2	1.15	0.61–2.17	0.660	0	0.93	0.72–1.19	0.557	55.5	1.18	0.62–2.21	0.616	0
Ethnicity
China	6	1.08	0.88–1.33	0.439	70.4	1.06	0.81–1.39	0.676	74.7	1.32	1.00–1.74	0.053	0	1.08	0.84–1.39	0.555	75.1	1.24	0.94–1.63	0.130	0
Design
PB	3	1.29	1.13–1.41	<0.001	32.4	1.34	1.14–1.57	<0.001	43.4	1.40	1.01–1.96	0.045	0	1.34	1.05–1.57	<0.001	45.8	1.29	0.92–1.79	0.136	0
HB	4	0.97	0.77–1.21	0.550	52.2	0.92	0.69–1.22	0.554	57.3	1.20	0.74–1.94	0.466	0	0.84	0.72–1.23	0.643	58.1	1.20	0.74–1.94	0.456	0
Location
Gastric	4	1.29	1.14–1.46	<0.001	0	1.33	1.13–1.55	<0.001	21.6	1.40	1.04–1.88	0.026	0	1.34	1.16–1.55	<0.001	16	1.30	0.97–1.74	0.082	0
Others	3	0.91	0.70–1.18	0.472	57.4	0.88	0.62–1.24	0.460	69.2	1.02	0.50–2.08	0.962	0	0.89	0.64–1.22	0.461	66.7	1.04	0.51–2.13	0.905	0

∗Numbers of comparisons.
^aTest for heterogeneity.