Figure 3: Deleterious effects of recombinant sTWEAK on myocardial function and survival after MI. (a) Recombinant sTWEAK (or vehicle (NaCL)) was injected every 3 days i.p. at a dose of 200 μg/kg body weight for each injection starting 1 day after induction of myocardial infarction in mice. (b) Treatment of mice with recombinant sTWEAK for 28 days resulted in significantly increased mortality after myocardial infarction compared to control animals ( sTWEAK versus NaCL). No changes in the degree of myocardial hypertrophy could be observed. (c) Echocardiographic analysis revealed reduced left ventricular function and increased left ventricular end-diastolic diameters (LVEDD) (both ; sham + NaCL ; sham + rsTWEAK ; LAD + NaCL ; LAD + rsTWEAK ).