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Mediators of Inflammation
Volume 2014, Article ID 143463, 11 pages
http://dx.doi.org/10.1155/2014/143463
Research Article

Interaction with Mesenchymal Stem Cells Provokes Natural Killer Cells for Enhanced IL-12/IL-18-Induced Interferon-Gamma Secretion

1Orthopedic Research, Department of Orthopedics, University Hospital Essen, University Duisburg-Essen, Virchowstraße 171, 45147 Essen, Germany
2Surgical Research, Department of Trauma Surgery, University Hospital Essen, University Duisburg-Essen, Virchowstraße 171, 45147 Essen, Germany
3Department of Otolaryngology, University Hospital Essen, University Duisburg-Essen, Virchowstraße 171, 45147 Essen, Germany

Received 23 January 2014; Revised 2 April 2014; Accepted 8 April 2014; Published 30 April 2014

Academic Editor: Jonathan Peake

Copyright © 2014 Heike Thomas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. F. P. Barry, “Biology and clinical applications of mesenchymal stem cells,” Birth Defects Research C: Embryo Today, vol. 69, no. 3, pp. 250–256, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. J. D. Brandstadter and Y. Yang, “Natural killer cell responses to viral infection,” Journal of Innate Immunity, vol. 3, no. 3, pp. 274–279, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. M. A. Cooper, T. A. Fehniger, A. Ponnappan et al., “Interleukin-1beta costimulates interferon-gamma production by human natural killer cells,” European Journal of Immunology, vol. 31, pp. 792–801, 2001. View at Google Scholar
  4. T. A. Fehniger, M. H. Shah, M. J. Turner et al., “Differential cytokine and chemokine gene expression by human NK cells following activation with IL-18 or IL-15 in combination with IL-12: implications for the innate immune response,” Journal of Immunology, vol. 162, no. 8, pp. 4511–4520, 1999. View at Google Scholar · View at Scopus
  5. K. S. Wang, D. A. Frank, and J. Ritz, “Interleukin-2 enhances the response of natural killer cells to interleukin-12 through up-regulation of the interleukin-12 receptor and STAT4,” Blood, vol. 95, no. 10, pp. 3183–3190, 2000. View at Google Scholar · View at Scopus
  6. D. H. Presky, H. Yang, L. J. Minetti et al., “A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits,” Proceedings of the National Academy of Sciences of the United States of America, vol. 93, no. 24, pp. 14002–14007, 1996. View at Google Scholar · View at Scopus
  7. M. Nakahira, H.-J. Ahn, W.-R. Park et al., “Synergy of IL-12 and IL-18 for IFN-γ gene expression: IL-12-induced STAT4 contributes to IFN-γ promoter activation by up-regulating the binding activity of IL-18-induced activator protein 1,” Journal of Immunology, vol. 168, no. 3, pp. 1146–1153, 2002. View at Google Scholar · View at Scopus
  8. S. Akira, “The role of IL-18 in innate immunity,” Current Opinion in Immunology, vol. 12, pp. 59–63, 2000. View at Google Scholar
  9. J. Yu, M. Wei, B. Becknell et al., “Pro- and antiinflammatory cytokine signaling: reciprocal antagonism regulates interferon-gamma production by human natural killer cells,” Immunity, vol. 24, no. 5, pp. 575–590, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. M. H. Kaplan, Y.-L. Sun, T. Hoey, and M. J. Grusby, “Impaired IL-12 responses and enhanced development of Th2 cells in Stat4- deficient mice,” Nature, vol. 382, no. 6587, pp. 174–177, 1996. View at Publisher · View at Google Scholar · View at Scopus
  11. M. A. Degli-Esposti and M. J. Smyth, “Close encounters of different kinds: dendritic cells and NK cells take centre stage,” Nature Reviews Immunology, vol. 5, no. 2, pp. 112–124, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. T. Walzer, M. Dalod, S. H. Robbins, L. Zitvogel, and E. Vivier, “Natural-killer cells and dendritic cells: ‘L'union fait la force’,” Blood, vol. 106, no. 7, pp. 2252–2258, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Cheng, M.-H. Nguyen, G. Fantuzzi, and T. J. Koh, “Endogenous interferon-γ is required for efficient skeletal muscle regeneration,” The American Journal of Physiology—Cell Physiology, vol. 294, no. 5, pp. C1183–C1191, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. G. Duque, D. C. Huang, N. Dion et al., “Interferon-Î plays a role in bone formation in vivo and rescues osteoporosis in ovariectomized mice,” Journal of Bone and Mineral Research, vol. 26, no. 7, pp. 1472–1483, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. Liu, L. Wang, T. Kikuiri et al., “Mesenchymal stem cell-based tissue regeneration is governed by recipient T lymphocytes via IFN-γ and TNF-α,” Nature Medicine, vol. 17, no. 12, pp. 1594–1601, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Jewett, Y. G. Man, and H. C. Tseng, “Dual functions of natural killer cells in selection and differentiation of stem cells, role in regulation of inflammation and regeneration of tissues,” Journal of Cancer, vol. 4, pp. 12–24, 2013. View at Google Scholar
  17. N. Kim, K. I. Im, J. Y. Lim et al., “Mesenchymal stem cells for the treatment and prevention of graft-versus-host disease: experiments and practice,” Annals of Hematology, vol. 92, pp. 1295–1308, 2013. View at Google Scholar
  18. K. le Blanc and O. Ringdén, “Immunomodulation by mesenchymal stem cells and clinical experience,” Journal of Internal Medicine, vol. 262, no. 5, pp. 509–525, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Abumaree, M. Al Jumah, R. A. Pace, and B. Kalionis, “Immunosuppressive properties of mesenchymal stem cells,” Stem Cell Reviews, vol. 8, pp. 375–392, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. S. Aggarwal and M. F. Pittenger, “Human mesenchymal stem cells modulate allogeneic immune cell responses,” Blood, vol. 105, no. 4, pp. 1815–1822, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Krampera, L. Cosmi, R. Angeli et al., “Role for interferon-γ in the immunomodulatory activity of human bone marrow mesenchymal stem cells,” Stem Cells, vol. 24, no. 2, pp. 386–398, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. G. M. Spaggiari, A. Capobianco, S. Becchetti, M. C. Mingari, and L. Moretta, “Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation,” Blood, vol. 107, no. 4, pp. 1484–1490, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Poggi, C. Prevosto, A.-M. Massaro et al., “Interaction between human NK cells and bone marrow stromal cells induces NK cell triggering: role of NKp30 and NKG2D receptors,” Journal of Immunology, vol. 175, no. 10, pp. 6352–6360, 2005. View at Google Scholar · View at Scopus
  24. O. DelaRosa, B. Sanchez-Correa, S. Morgado et al., “Human adipose-derived stem cells impair natural killer cell function and exhibit low susceptibility to natural killer-mediated lysis,” Stem Cells and Development, vol. 21, pp. 1333–1343, 2012. View at Google Scholar
  25. G. M. Spaggiari, A. Capobianco, H. Abdelrazik, F. Becchetti, M. C. Mingari, and L. Moretta, “Mesenchymal stem cells inhibit natural killer-cell proliferation, cytotoxicity, and cytokine production: role of indoleamine 2,3-dioxygenase and prostaglandin E2,” Blood, vol. 111, no. 3, pp. 1327–1333, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. E. Pastille, S. Didovic, D. Brauckmann et al., “Modulation of dendritic cell differentiation in the bone marrow mediates sustained immunosuppression after polymicrobial sepsis,” Journal of Immunology, vol. 186, no. 2, pp. 977–986, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. H. S. Kang, M. Habib, J. Chan et al., “A paradoxical role for IFN-γ in the immune properties of mesenchymal stem cells during viral challenge,” Experimental Hematology, vol. 33, no. 7, pp. 796–803, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. M. A. Caligiuri, “Human natural killer cells,” Blood, vol. 112, no. 3, pp. 461–469, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. S. J. Szabo, S. T. Kim, G. L. Costa, X. Zhang, C. G. Fathman, and L. H. Glimcher, “A novel transcription factor, T-bet, directs Th1 lineage commitment,” Cell, vol. 100, no. 6, pp. 655–669, 2000. View at Google Scholar · View at Scopus
  30. S. J. Szabo, B. M. Sullivan, C. Sternmann, A. R. Satoskar, B. P. Sleckman, and L. H. Glimcher, “Distinct effects of T-bet in Th1 lineage commitment and IFN-γ production in CD4 and CD8 T cells,” Science, vol. 295, no. 5553, pp. 338–342, 2002. View at Publisher · View at Google Scholar · View at Scopus
  31. M. Afkarian, J. R. Sedy, J. Yang et al., “T-bet is a STATI-induced regulator for IL-12R expression in naïve CD4+ T cells,” Nature Immunology, vol. 3, no. 6, pp. 549–557, 2002. View at Publisher · View at Google Scholar · View at Scopus
  32. W. E. Thierfelder, J. M. van Deursen, K. Yamamoto et al., “Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells,” Nature, vol. 382, no. 6587, pp. 171–174, 1996. View at Publisher · View at Google Scholar · View at Scopus
  33. R. Meisel, S. Brockers, K. Heseler et al., “Human but not murine multipotent mesenchymal stromal cells exhibit broad-spectrum antimicrobial effector function mediated by indoleamine 2,3-dioxygenase,” Leukemia, vol. 25, no. 4, pp. 648–654, 2011. View at Google Scholar · View at Scopus
  34. G. Duque, D. C. Huang, M. Macoritto et al., “Autocrine regulation of interferon γ in mesenchymal stem cells plays a role in early osteoblastogenesis,” Stem Cells, vol. 27, no. 3, pp. 550–558, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. Jasmin, L. A. Jelicks, W. Koba et al., “Mesenchymal bone marrow cell therapy in a mouse model of chagas disease. Where do the cells go?” PLoS Neglected Tropical Diseases, vol. 6, Article ID e1971, 1971. View at Publisher · View at Google Scholar