Oxidative Stress Markers and C-Reactive Protein Are Related to Severity of Heart Failure in Patients with Dilated Cardiomyopathy

Table 4

Redox biomarkers and hs-CRP in healthy controls and all DCM patients and with division of them into groups depending on NYHA class and LVEF.

	Control; C; ()	DCM; D; ()	NYHA; I-II; A ()	NYHA; III-IV; B ()	“” Mann-Whitney T	LVEF; ≥20%; A1 ()	LVEF; <20%; B1 ()	“” Mann-Whitney T
MDA; mol/L]	1.31; 1.14–1.41	4.37; 3.68–5.78	4.47; 3.71–5.61	4.26; 3.51–5.78	^AvsBns; <0.001; ^BvsC<0.001; ^DvsC<0.001	4.51; 3.71–5.27	4.00; 3.70–5.29	^A1vsB1ns; ^A1vsC<0.001; ^B1vsC<0.001
UA; mol/L]	296; 266–330	427; 345–500	397; 331–471	462,0; 358–566	^AvsB<0.05; ^AvsC<0.001; ^BvsC<0.001; ^DvsC<0.001	398; 334–480	462; 409–590	^A1vsB1<0.01; ^A1vsC<0.001; ^B1vsC<0.001
MnSOD; NU/mL]	8.89; 7.76–9.70	9.04; 4.16–13.74	7.23; 3.49–12.65	10.52; 5.91–14.82	^AvsB<0.05; ^AvsCns; ^BvsC<0.05; ^DvsCns	6.58; 3.09–11.69	11.39; 5.92–15.76	^A1vsB1<0.001; ^A1vsCns; ^B1vsC<0.05
CuZnSOD; NU/mL]	5.37; 3.09–5.95	4.88; 2.60–6.79	4.72; 2.49–6.1	5.92; 3.88–7.3	^AvsBns; ^AvsCns; ^BvsCns; ^DvsCns	4.55; 2.49–6.12	6.52; 3.47–8.53	^A1vsB1<0.05; ^A1vsCns; ^B1vsCns
hs-CRP; mg/L]	0.76; 0.53–1.53	1.7; 0.71–4.34	1.45; 0.47–3.27	2.7; 1.11–9.68	^AvsB<0.05; ^AvsC<0.05; ^BvsC<0.01; ^DvsC<0.05	1.85; 0.71–3.10	3.29; 2.00–5.70	^A1vsB1<0.01; ^A1vsC<0.01; ^B1vsC<0.001

MDA: malondialdehyde; UA: uric acid; MnSOD: manganese superoxide dismutase; CuZnSOD: cooper-zinc superoxide dismutase; hs-CRP: high sensitivity C-reactive protein.