Research Article
Oxidative Stress Markers and C-Reactive Protein Are Related to Severity of Heart Failure in Patients with Dilated Cardiomyopathy
Table 4
Redox biomarkers and hs-CRP in healthy controls and all DCM patients and with division of them into groups depending on NYHA class and LVEF.
| | Control C () | DCM D () | NYHA I-II A () | NYHA III-IV B () | “” Mann-Whitney T | LVEF ≥20% A1 () | LVEF <20% B1 () | “” Mann-Whitney T |
| MDA mol/L] | 1.31 1.14–1.41 | 4.37 3.68–5.78 | 4.47 3.71–5.61 | 4.26 3.51–5.78 |
AvsBns <0.001 BvsC<0.001 DvsC<0.001 | 4.51 3.71–5.27 | 4.00 3.70–5.29 |
A1vsB1ns A1vsC<0.001 B1vsC<0.001 |
| UA mol/L] | 296 266–330 | 427 345–500 | 397 331–471 | 462,0 358–566 |
AvsB<0.05 AvsC<0.001 BvsC<0.001 DvsC<0.001 | 398 334–480 | 462 409–590 |
A1vsB1<0.01 A1vsC<0.001 B1vsC<0.001 |
| MnSOD NU/mL] | 8.89 7.76–9.70 | 9.04 4.16–13.74 | 7.23 3.49–12.65 | 10.52 5.91–14.82 |
AvsB<0.05 AvsCns BvsC<0.05 DvsCns | 6.58 3.09–11.69 | 11.39 5.92–15.76 |
A1vsB1<0.001 A1vsCns B1vsC<0.05 |
| CuZnSOD NU/mL] | 5.37 3.09–5.95 | 4.88 2.60–6.79 | 4.72 2.49–6.1 | 5.92 3.88–7.3 |
AvsBns AvsCns BvsCns DvsCns | 4.55 2.49–6.12 | 6.52 3.47–8.53 |
A1vsB1<0.05 A1vsCns B1vsCns |
| hs-CRP mg/L] | 0.76 0.53–1.53 | 1.7 0.71–4.34 | 1.45 0.47–3.27 | 2.7 1.11–9.68 |
AvsB<0.05 AvsC<0.05 BvsC<0.01 DvsC<0.05 | 1.85 0.71–3.10 | 3.29 2.00–5.70 |
A1vsB1<0.01 A1vsC<0.01 B1vsC<0.001 |
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MDA: malondialdehyde; UA: uric acid; MnSOD: manganese superoxide dismutase; CuZnSOD: cooper-zinc superoxide dismutase; hs-CRP: high sensitivity C-reactive protein.
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