Oxidative Stress Markers and C-Reactive Protein Are Related to Severity of Heart Failure in Patients with Dilated Cardiomyopathy

Table 5

Spearman correlation between biomarkers and left ventricle ejection fraction and hemodynamic parameters.

	NT-proBNP	Uric acid	CRP	SvO2	MnSOD	CuZnSOD	MDA
LVEF	−0.547; P < 0.001	−0.285; P < 0.01	−0.240; P < 0.05	0.027; NS	−0.251; P < 0.05	−0.190; P = 0.051	0.114; NS
mPAP	0.548; P < 0.001	0.236; P < 0.05	0.161; NS	−0.262; P < 0.05	0.252; P < 0.01	0.243; P < 0.05	−0.029; NS
mABP	−0.373; P < 0.001	0.114; NS	−0.225; NS	0.191; NS	−0.085; NS	0.021; NS	−0.039; NS
PWP	0.563; P < 0.001	0.167; NS	0.084; NS	−0.224; P < 0.05	0.239; P < 0.05	0.247; P < 0.05	−0.037; NS
PVRI	0.252; P < 0.05	0.236; P < 0.05	0.236; P < 0.05	−0.354; P < 0.001	0.096; NS	0.015; NS	0.014; NS
SVRI	0.177; NS	0.194; NS	−0.218; NS	−0.262; P < 0.05	−0.012; NS	0.035; NS	−0.098; NS
CI	−0.544; P < 0.001	−0.193; NS	0.072; NS	0.428; P < 0.001	−0.064; NS	−0.084; NS	0.079; NS

NT-proBNP: N-terminal pro-B-type natriuretic peptide; CRP: C-reactive protein; SvO₂: mixed venous blood saturation; MnSOD: manganese superoxide dismutase; CuZnSOD: cooper-zinc superoxide dismutase; MDA: malondialdehyde; LVEF: left ventricle ejection fraction; mPAP: mean pulmonary artery pressure; mABP: mean arterial blood pressure; PWP: pulmonary wedge pressure; PVRI: pulmonary vascular resistance index; SVRI: systemic vascular resistance index; CI: cardiac index.