Early Activation of Pulmonary TGF-β1/Smad2 Signaling in Mice with Acute Pancreatitis-Associated Acute Lung Injury

Table 1

Changes in expression patterns of TGF-β signaling molecules in the lungs during acute pancreatitis at two time points. The expression of TGF-β signaling molecules in the lungs of AP compared to sham-operated animals based on immunohistochemistry and Western blot analyses at 9 and 24 h. AP: acute pancreatitis.

	9 h	24 h
TGF-β1	↑ Expression in AP (𝑃<0.05)	↑↑ Expression in AP (𝑃<0.01)
TGF-β2 and 3	No difference between sham and AP	No difference between sham and AP
TβRII	No difference between sham and AP	No difference between sham and AP
ALK-5	↑ Expression in AP, ↑↑ positive cells in AP (𝑃<0.001)	↑↑ Expression in AP, ↑↑ positive cells in AP (𝑃<0.05)
Smad2, 3 and 4	No difference between sham and AP	No difference between sham and AP
Smad7	↑ Expression in AP (𝑃<0.05)	No difference between sham and AP
P-Smad2	No difference between sham and AP	↑ Nuclear translocation in AP