(v) Induced apoptosis through an intrinsic pathway in gastric cancer cell lines [11].
(vi) Exhibited caspase-independent death of human osteosarcoma cells via p53-mediated mitochondrial stress and nuclear translocation of AIF and endonuclease G [12].
(vii) Enhanced mitochondrial mediated apoptosis by inhibition of the PI3K-Akt/PKB survival pathway in gastric cancer cell lines [13].
(i) Suppressed proinflammatory mediators NO, PGE2, and TNF-α via inhibition of NF-B and JNK pathway in LPS-induced RAW 264.7 macrophages [18].
(ii) Inhibited ROS production and PKC- translocation, downregulated the expression of NF-B and AP-1, and inhibited the levels of iNOS and COX-2 expression [19].
(iii) Inhibited the expressions of TNF-, IL-6, and IL-8 on human mast cells with treatment with PMA and A23187 [20].
(iv) Inhibited LPS-induced NO, PGE2, TNF-, and IL-1 production via the induction of HO-1 expression in murine macrophages [21].
(v) Suppressed NOS via the ERK and Akt signaling pathways [22].
(vi) Suppressed iNOS and COX2 mRNA expression induced by LPS and decreased intracellular ROS levels induced by LPS [17].
(vii) Inhibited inflammation-related cytokines and angiogenic factor in rheumatoid arthritic fibroblast-like synovial cells [23].
(i) Exhibited the inhibition of hydroxyl radical-mediated degradation by iron ion chelation [25].
(ii) Exhibited the inhibition of linoleic acid oxidation, protected human LDL from oxidative modification, and protected against plasmid DNA strand breakage induced by peroxyl free radicals [26].
(iii) Exhibited against hydroxyl and peroxyl radicals in in vitro assays [7].
(iv) Inhibited activities of NF-B and AP-1 induced by G/GO [27].
(v) Reduced intracellular ROS formation caused by H2O2, reduced TBARS formation, and attenuated catalase depletion at concentration of 100 /mL [28].
(vi) Prevented cisplatin-induced ROS release against MDCK-I cells [29].
(vii) Protected human keratinocytes against oxidative stress caused by H2O2 [30].
Antiviral
Exhibited antiviral activity against fish pathogenic IHNV and VHSV [31].
Neuroprotection
(i) Protected the murine hippocampal HT22 cells against glutamate-induced neurotoxicity [32].
(ii) Protected dopaminergic neuronal cells in a rotenone model of PD [33].
(iii) Protected against 6-OHDA-induced neuronal cell death of PD [34].
(iv) Protected against rotenone-induced toxicity by preventing the downregulation of BDNF and GDNF in human dopaminergic cells, SH-SY5Y [35, 36].
Other activities
(i) Inhibited platelet aggregation via inhibition of receptor expression on platelet membranes, including glycoprotein IIb/IIIa (CD41), GPIIb/IIIa-like expression (PAC-1), and P-selectin (CD62), and intracellular calcium mobilization responses and decreased platelet activation were observed for the isomaltol- and pentagalloyl glucose-treated platelets [37].
(ii) Exhibited anti-AKR1B10 activity at 1 M with an IC50 value of 1.47 M [38].
(iii) Suppressed IL-4 and -10 in BPA-stimulated primary cultured mouse lymphocytes [39].