Role of TGF-β Pathway Polymorphisms in Sporadic Thoracic Aortic Aneurysm: rs900 TGF-β2 Is a Marker of Differential Gender Susceptibility
Table 6
Statistical analysis of TGF-2 rs900 genotype distributions in patients affected by TAA and in the two groups of control subjects stratified according to the gender*.
Men
Women
AA
AT
TT
AA
AT
TT
TAA patients (%)
36 (33.65)
54 (50.46)
17 (15.89)
8 (21.62)
16 (43.24)
13 (35.13)
Control patients (%)
22 (39.29)
25 (44.64)
9 (16.07)
18 (52.94)
11 (32.35)
5 (14.71)
Healthy controls (%)
43 (38.39)
56 (50.00)
13 (11.61)
34 (60.71)
17 (30.36)
5 (8.93)
Odd ratio significance
Men
Women
AA
AT
TT
AA
AT
TT
TAA versus control patients
OR
0.784
1.263
0.986
0.245
1.263
3.142
95% C.I.
0.401–1.531
0.660–2.418
0.408–2.382
0.087–0.689
0.660–2.418
0.990–10.071
value
0.495
0.512
1.000
0.0076
0.512
0.059
TAA versus healthy controls
OR
0.814
1.019
1.438
0.178
1.019
5.525
95% C.I.
0.468–1.415
0.401–1.531
0.662–3.128
0.069–0.461
0.600–1.731
1.767–17.272
value
0.484
1.000
0.433
0.0003
1.000
0.0027
Logistic regression analysis adjusted for gender confirms that the AA genotype frequency was significantly decreased and TT genotype increased in TAA women patients compared to women of the two control groups (), in particular compared to healthy controls ().
