Impact of Wines and Wine Constituents on Cyclooxygenase-1, Cyclooxygenase-2, and 5-Lipoxygenase Catalytic Activity

<table>Docking pose of piceatannol in 5-LOX. Yellow spheres signify hydrophobic interactions with the binding pocket. The blue circle marks an aromatic interaction with the binding pocket. The green arrow signifies a hydrogen bond donor interaction with Gln557. The red arrow signifies a hydrogen bond acceptor interaction with Asn425.</table>

Mediators of Inflammation

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Figure 1

Figure 1: Impact of Wines and Wine Constituents on Cyclooxygenase-1, Cyclooxygenase-2, and 5-Lipoxygenase Catalytic Activity 