Impact of Wines and Wine Constituents on Cyclooxygenase-1, Cyclooxygenase-2, and 5-Lipoxygenase Catalytic Activity

Table 3

IC₅₀ values of wine constituents and reference inhibitors for COX-1, COX-2, and 5-LOX.

Compound	IC50  ± SD (𝜇M)		Ratio	IC50  ± SD (𝜇M)
	COX-1	COX-2	COX-1/COX-2	5-LOX
Resveratrol	2.27±1.17	3.40±0.50	0.67	—
Piceatannol	—*	—		0.76 ± 0.35
Luteolin	—	—		2.25 ± 1.75
Quercetin	—	—		3.29 ± 2.25
Myricetin	—	—		4.02 ± 2.37
Kaempferol	43.82±18.81	—		—
Ibuprofen	13.14±3.84	8.77±2.55	1.49	nt^#
Indomethacin	1.61±0.72	10.12±5.66	0.15	nt
Zileuton	nt	nt		4.71±2.83

Data is presented as the mean value ± SD. ∗IC₅₀ > 50 𝜇M concentration; #not tested.