Research Article
Serum Matrix Metalloproteinase-3 as a Noninvasive Biomarker of Histological Synovitis for Diagnosis of Rheumatoid Arthritis
Table 3
Multiple linear regression analysis of variables associated with synovial MMP-3.
| Variable |
Unstandardized coefficients | Standardized coefficients | | | 95% CI | | Std. error |
| Components of synovitis score | | | | | | | Hyperplasia of lining layer | — | — | — | 1.767 | 0.083 | — | Inflammatory infiltration | — | — | — | 0.361 | 0.719 | — | Activation of synovial stroma | 6.226 | 1.568 | 0.374 | 3.970 | <0.001 | 3.086~9.366 | Sublining inflammatory cells | | | | | | | CD3+ T cells | — | — | — | 0.948 | 0.347 | — | CD38+ plasma cells | — | — | — | 0.528 | 0.599 | — | CD68+ macrophages | 0.006 | 0.002 | 0.284 | 3.016 | 0.004 | 0.002~0.009 | CD15+ neutrophils | 0.022 | 0.006 | 0.368 | 3.897 | <0.001 | 0.011~0.033 | Constant | 26.071 | 2.645 | — | 9.857 | <0.001 | 20.775~31.368 |
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