Mediators of Inflammation / 2014 / Article / Fig 5

Research Article

MSH Blunts Endotoxin-Induced MuRF1 and Atrogin-1 Upregulation in Skeletal Muscle by Modulating NF-B and Akt/FoxO1 Pathway

Figure 5

PhosphoFoxO1 (a), total FoxO1 (b), and FoxO1 mRNA levels (c) in gastrocnemius muscle of control, LPS and pair-fed (PF) rats treated with αMSH (100 μg/kg) or saline. LPS decreased pFoxO1 , whereas it increased FoxO1 and FoxO1 mRNA in rats treated with saline. αMSH administration prevented LPS-induced increase in FoxO1 and its mRNA. Data represent mean SEM ( 8–10 rats). ** and *, LSD multiple comparison test.

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