The Pathology of Orthopedic Implant Failure Is Mediated by Innate Immune System Cytokines

Figure 3

Schematic of intracellular innate immune responses to implant debris (metal ions and particles) that produce both DAMP and PAMP pathway activations through lysosomal destabilization (DAMPs) and either TLR or cytokine receptor activation (PAMPs), resulting in the collaborative interaction of the inflammasome and NF-𝜅B pathways (courtesy of Bioengineering Solutions Inc.).