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Mediators of Inflammation
Volume 2014, Article ID 185758, 7 pages
Research Article

Chemokines Profiling of Patients with Preterm Birth

1Department of Perinatology and Obstetrics, Medical University of Bialystok, Bialystok, 15-276 Podlasie, Poland
2Department of Perinatology and Obstetrics, Medical University of Bialystok, Marii Sklodowskiej Curie 24a, 15-273 Bialystok, Poland
3Faculty of Computer Science, Bialystok University of Technology, Bialystok, 15-351 Podlasie, Poland
4Institute of Obstetric and Emergency Medicine, University of Rzeszow, Żurawica, 37-710 Podkarpackie, Poland
5Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, Lublin, 20-081 Lubelskie, Poland

Received 30 December 2013; Revised 6 April 2014; Accepted 6 April 2014; Published 28 April 2014

Academic Editor: Chiara De Luca

Copyright © 2014 Piotr Laudanski et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. Nowadays it is thought that the main cause of premature birth is subclinical infection. However, none of the currently used methods provide effective prevention to preterm labor. The aim of the study was to determine the concentration of selected chemokines in sera of patients with premature birth without clinical signs of infection (), threatened preterm labor (), and term births (). Method. To assess the concentration of chemokines in the blood serum, we used a multiplex method, which allows the simultaneous determination of 40 chemokines per sample. The sets consist of the following chemokines: 6Ckine/CCL21, Axl, BTC, CCL28, CTACK/CCL27, CXCL16, ENA-78/CXCL5, Eotaxin-3/CCL26, GCP-2/CXC, GRO (GROα/CXCL1, GROβ/CXCL2 and GROγ/CXCL3), HCC-1/CCL14, HCC-4/CCL16, IL-9, IL-17F, IL18-BPa, IL-28A, IL-29, IL-31, IP-10/CXCL10, I-TAC/CXCL11, LIF, LIGHT/TNFSF14, Lymphotactin/XCL1, MCP-2/CCL8, MCP-3/CCL7, MCP-4/CCL13, MDC/CCL22, MIF, MIP-3α/CCL20, MIP-3-β/CCL19, MPIF-1/CCL23, NAP-2/CXCL7, MSPα, OPN, PARC/CCL18, PF4, SDF-1/CXCL12, TARC/CCL17, TECK/CCL25, and TSLP. Results. We showed possible implication of 4 chemokines, that is, HCC-4, I-TAC, MIP-3α, and TARC in women with symptoms of preterm delivery. Conclusion. On the basis of our findings, it seems that the chemokines may play role in the pathogenesis of preterm labor. Defining their potential as biochemical markers of preterm birth requires further investigation on larger group of patients.