Synthetic Phage for Tissue Regeneration

Table 1

Selected reports of peptides identified or constructed by synthetic phages.

Peptide sequence	Engineering type	Targeted protein	Biological activity	Potential applications	References
RGD	3 and 8	Integrin 𝛼𝑉𝛽1	Cellular adhesion, fibronectin like	Tissue engineering, regeneration, receptor-mediated endocytosis	[12–15]
IKVAV	8	Integrin 𝛼6𝛽4	Cellular adhesion, laminin like	Tissue engineering, neural cell differentiation	[12]
DGEA	8	Integrin 𝛼2𝛽1	Cellular adhesion, collagen type I like	Tissue engineering, osteogenic differentiation	[16]
HPQ	3 and 8	Streptavidin	Streptavidin binding, biotin like	Tissue engineering, conjugating growth factors	[14, 17]
RLIVGDPSSFQEKDADTL	3	Chlamydia	Ameliorating chlamydia infection	Prevention and treatment of Chlamydia trachomatis, microbicides	[15]
YWQPYALPL	3 and 8	IL-1R type I	Antagonists	Anti-inflammatory effects	[11]
KRTGQYKL	3	FGFR	Antagonists	Cancer therapy; inhibition of angiogenesis and tumor progression	[18]
GERWCFDGPRAWVCGWEI,; GGNECDIARMWEWECFERL,; RGWVEICAADDYGRCLTEAQ	8 + 8 and; 3 + 3	VEGFR	Indirect antagonists	Cancer therapy; inhibition of angiogenesis and cellular proliferation	[19]
GGCADGPTLREWISFCGG	8 + 8	TpoR	Agonist	Treatment of idiopathic	[20]
AFDWTFVPSLIL	3	CCR5	Antagonist	Anti-inflammatory effects, prevention of HIV-1 entry to CD4+ cells; treatment of multiple sclerosis, rheumatoid arthritis, HCV and HIV infections, prevention of renal allograft rejection	[21]
QEVCMTSCDKLMKCNWMAAM	8 + 8 and; 3 + 3	DR5	Agonist	Cancer therapy; triggering of apoptosis in tumor cells	[22]
TAWSEVLDLLRR	3	PMCA4	Allosteric; inhibitor	Study of physiological PMCA4 function, study of arterial hypertension mechanisms and retinopathies, development of new class of contraceptives	[23–25]
SSCESPEVDYLECLY,; LQCRYDQLIEEWRCEY	8 + 8	B-cell maturation antigen	Indirect antagonists	Cancer therapy; inhibition of APRIL (a proliferation-inducing; ligand)-stimulated proliferation	[26]