Table 1: Selected reports of peptides identified or constructed by synthetic phages.

Peptide sequenceEngineering typeTargeted proteinBiological activityPotential applicationsReferences

RGD3 and 8Integrin Cellular adhesion, fibronectin likeTissue engineering, regeneration, receptor-mediated endocytosis[1215]

IKVAV8Integrin Cellular adhesion, laminin likeTissue engineering, neural cell differentiation[12]

DGEA8Integrin Cellular adhesion, collagen type I likeTissue engineering, osteogenic differentiation[16]

HPQ3 and 8StreptavidinStreptavidin binding, biotin likeTissue engineering, conjugating growth factors[14, 17]

RLIVGDPSSFQEKDADTL3ChlamydiaAmeliorating chlamydia infectionPrevention and treatment of Chlamydia trachomatis, microbicides[15]

YWQPYALPL3 and 8IL-1R type IAntagonistsAnti-inflammatory effects[11]

KRTGQYKL3FGFRAntagonistsCancer therapy; inhibition of angiogenesis and tumor progression[18]

GERWCFDGPRAWVCGWEI,
GGNECDIARMWEWECFERL,
RGWVEICAADDYGRCLTEAQ
8 + 8 and
3 + 3
VEGFRIndirect antagonistsCancer therapy; inhibition of angiogenesis and cellular proliferation[19]

GGCADGPTLREWISFCGG8 + 8TpoRAgonistTreatment of idiopathic[20]

AFDWTFVPSLIL3CCR5AntagonistAnti-inflammatory effects, prevention of HIV-1 entry to CD4+ cells; treatment of multiple sclerosis, rheumatoid arthritis, HCV and HIV infections, prevention of renal allograft rejection[21]

QEVCMTSCDKLMKCNWMAAM8 + 8 and
3 + 3
DR5AgonistCancer therapy; triggering of apoptosis in tumor cells[22]

TAWSEVLDLLRR3PMCA4Allosteric
inhibitor
Study of physiological PMCA4 function, study of arterial hypertension mechanisms and retinopathies, development of new class of contraceptives[2325]

SSCESPEVDYLECLY,
LQCRYDQLIEEWRCEY
8 + 8B-cell maturation antigenIndirect antagonistsCancer therapy; inhibition of APRIL (a proliferation-inducing
ligand)-stimulated proliferation
[26]