Blockade of ICAM-1 Improves the Outcome of Polymicrobial Sepsis via Modulating Neutrophil Migration and Reversing Immunosuppression
Figure 2
Anti-ICAM-1 antibody treatment improved survival (a) and bacterial clearance (b) in CLP mice. (a) The 7-day survival rates were compared among anti-ICAM-1 antibody treated CLP mice, isotype antibody treated CLP mice, saline treated mice, and sham-operated mice. per each group. when anti-ICAM-1 antibody treated mice were compared with mice treated with isotype antibody or saline. (b) Bacterial clearance was compared among anti-ICAM-1 antibody treated CLP mice, isotype antibody treated CLP mice, saline treated mice, and sham-operated mice 24 h after surgery. per each group. PLF: peritoneal lavage fluid. when anti-ICAM-1 antibody treated mice were compared with mice treated with isotype antibody or saline. Bars represent the mean ± SD.
