Blockade of ICAM-1 Improves the Outcome of Polymicrobial Sepsis via Modulating Neutrophil Migration and Reversing Immunosuppression
Figure 3
Anti-ICAM-1 antibody attenuated sepsis-induced lung injury as demonstrated by histopathological tests and wet-to-dry weight ratio. (a) The lungs of the anti-ICAM-1 antibody treated CLP mice, isotype antibody treated CLP mice, saline treated CLP mice, and sham-operated mice were harvested 24 h after surgery for histopathological staining. Histopathological tests showed milder impairment in lungs in anti-ICAM-1 group than in isotype and CLP groups. per each group. (b) Lung wet-to-dry weight ratio was reduced in anti-ICAM-1 group than in isotype and saline groups. when anti-ICAM-1 antibody treated mice were compared with mice treated with isotype antibody or saline. Bars represent the mean ± SD.
