Blockade of ICAM-1 Improves the Outcome of Polymicrobial Sepsis via Modulating Neutrophil Migration and Reversing Immunosuppression
Figure 5
Effect of ICAM-1 blockade on the immune status in thymus and spleen. (a) Representative sections analyzed by the in situ TUNEL assays. Apoptotic cells were significantly reduced by anti-ICAM-1 treatment in thymus and spleen. (b) RT-PCR assays of costimulatory molecules in thymus and spleen, including CD28, CD80, CD86, PD-1, and PD-L1. per each group. when anti-ICAM-1 antibody treated mice were compared with mice treated with isotype antibody or saline. Bars represent the mean ± SD.
