Potent Anti-Inflammatory and Antiproliferative Effects of Gambogic Acid in a Rat Model of Antigen-Induced Arthritis

<table><i>IL-1<i>β</i> and TNF secretion are inhibited by gambogic acid treatment.</i> Media samples from human THP-1 macrophage-like cell line cultured with growing concentrations of gambogic acid were analyzed by ELISA technique. Differences were considered statistically significant for <svg height="11.175" id="M12" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 10.9375 11.175" width="10.9375" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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t-10.5 -39.5l-43 -241q37 -13 83 -13q67 0 125.5 45t58.5 129z" id="x1D443"></path></g>
</svg> values &lt; 0.05.</table>

Mediators of Inflammation

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Figure 1

Figure 1: Potent Anti-Inflammatory and Antiproliferative Effects of Gambogic Acid in a Rat Model of Antigen-Induced Arthritis 