Potent Anti-Inflammatory and Antiproliferative Effects of Gambogic Acid in a Rat Model of Antigen-Induced Arthritis

<table><i>Gambogic acid is able to suppress inflammation throughout time.</i> After 6 days of treatment, the vehicle-injected group increased inflammatory manifestations, whereas, in gambogic acid-treated rats, there was a significant reduction in the inflammatory activity. Arrows indicate the beginning of treatment after 4 and 11 days of disease induction. Differences were considered statistically significant for <svg height="11.175" id="M24" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 10.9375 11.175" width="10.9375" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> values &lt; 0.05.</table>

Mediators of Inflammation

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Figure 3

Figure 3: Potent Anti-Inflammatory and Antiproliferative Effects of Gambogic Acid in a Rat Model of Antigen-Induced Arthritis 