Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2014, Article ID 195327, 7 pages
http://dx.doi.org/10.1155/2014/195327
Research Article

Potent Anti-Inflammatory and Antiproliferative Effects of Gambogic Acid in a Rat Model of Antigen-Induced Arthritis

1Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
2Gulbenkian Programme for Advanced Medical Education, Lisbon, Portugal
3Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA
4Rheumatology Department, Centro Hospitalar de Lisboa Norte, EPE, Hospital de Santa Maria, Lisbon, Portugal

Received 24 April 2013; Accepted 24 December 2013; Published 30 January 2014

Academic Editor: Sophie Desplat-Jégo

Copyright © 2014 Rita Cascão et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. Yelin and L. F. Callahan, “The economic cost and social and psychological impact of musculoskeletal conditions,” Arthritis & Rheumatism, vol. 38, no. 10, pp. 1351–1362, 1995. View at Publisher · View at Google Scholar · View at Scopus
  2. H. Radner, J. S. Smolen, and D. Aletaha, “Impact of comorbidity on physical function in patients with rheumatoid arthritis,” Annals of the Rheumatic Diseases, vol. 69, no. 3, pp. 536–541, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. E. Lindqvist, T. Saxne, P. Geborek, and K. Eberhardt, “Ten year outcome in a cohort of patients with early rheumatoid arthritis: health status, disease process, and damage,” Annals of the Rheumatic Diseases, vol. 61, no. 12, pp. 1055–1059, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. R. Goldbach-Mansky, “Blocking interleukin-1 in rheumatic diseases: its initial disappointments and recent successes in the treatment of autoinflammatory diseases,” Annals of the New York Academy of Sciences, vol. 1182, pp. 111–123, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. R. Cascão, R. A. Moura, I. Perpétuo et al., “Identification of a cytokine network sustaining neutrophil and Th17 activation in untreated early rheumatoid arthritis,” Arthritis Research & Therapy, vol. 12, no. 5, article R196, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. R. Cascão, J. Polido-Pereira, H. Canhao et al., “Caspase-1 is active since the early phase of rheumatoid arthritis,” Clinical and Experimental Rheumatology, vol. 30, no. 1, p. 144, 2012. View at Google Scholar
  7. Q.-B. Han, S. Cheung, J. Tai, C.-F. Qiao, J.-Z. Song, and H.-X. Xu, “Stability and cytotoxicity of gambogic acid and its derivative, gambogoic acid,” Biological and Pharmaceutical Bulletin, vol. 28, no. 12, pp. 2335–2337, 2005. View at Google Scholar · View at Scopus
  8. M. K. Pandey, B. Sung, K. S. Ahn, A. B. Kunnumakkara, M. M. Chaturvedi, and B. B. Aggarwal, “Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-κB signaling pathway,” Blood, vol. 110, no. 10, pp. 3517–3525, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. Q. Guo, Q. Qi, Q. You, H. Gu, L. Zhao, and Z. Wu, “Toxicological studies of gambogic acid and its potential targets in experimental animals,” Basic and Clinical Pharmacology and Toxicology, vol. 99, no. 2, pp. 178–184, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. J. A. Pereira da Silva, J. E. Fonseca, L. Graca, L. Moita, and M. Carmo-Fonseca, “Reinnervation of post-arthritis joints in the rat,” Clinical and Experimental Rheumatology, vol. 14, no. 1, pp. 43–51, 1996. View at Google Scholar · View at Scopus
  11. T. Tsubaki, N. Arita, T. Kawakami et al., “Characterization of histopathology and gene-expression profiles of synovitis in early rheumatoid arthritis using targeted biopsy specimens,” Arthritis Research & Therapy, vol. 7, no. 4, pp. R825–R836, 2005. View at Google Scholar · View at Scopus
  12. L. Zhang, Y. Yi, J. Chen et al., “Gambogic acid inhibits Hsp90 and deregulates TNF-α/NF-κB in HeLa cells,” Biochemical and Biophysical Research Communications, vol. 403, no. 3-4, pp. 282–287, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. N. Figueiredo, A. Chora, H. Raquel et al., “Anthracyclines induce DNA damage response-mediated protection against severe sepsis,” Immunity, vol. 39, pp. 874–884, 2013. View at Google Scholar
  14. H.-Z. Zhang, S. Kasibhatla, Y. Wang et al., “Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay,” Bioorganic and Medicinal Chemistry, vol. 12, no. 2, pp. 309–317, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Kasibhatla, K. A. Jessen, S. Maliartchouk et al., “A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 34, pp. 12095–12100, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. U. D. Palempall, U. Gandhi, P. Kalantari et al., “Gambogic acid covalently modifies IκB kinase-β subunit to mediate suppression of lipopolysaccharide-induced activation of NF-κB in macrophages,” Biochemical Journal, vol. 419, no. 2, pp. 401–409, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. K. Aya, M. Alhawagri, A. Hagen-Stapleton, H. Kitaura, O. Kanagawa, and D. V. Novack, “NF-κB-inducing kinase controls lymphocyte and osteoclast activities in inflammatory arthritis,” Journal of Clinical Investigation, vol. 115, no. 7, pp. 1848–1854, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. S. W. Tas, M. J. Vervoordeldonk, N. Hajji, M. J. May, S. Ghosh, and P. P. Tak, “Local treatment with the selective IκB kinase β inhibitor NEMO-binding domain peptide ameliorates synovial inflammation,” Arthritis Research & Therapy, vol. 8, no. 4, article R86, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. H. Okamoto, T. Iwamoto, S. Kotake, S. Momohara, H. Yamanaka, and N. Kamatani, “Inhibition of NK-κB signaling by fenofibrate, a peroxisome proliferator-activated receptor-α ligand, presents a therapeutic strategy for rheumatoid arthritis,” Clinical and Experimental Rheumatology, vol. 23, no. 3, pp. 323–330, 2005. View at Google Scholar · View at Scopus
  20. S. L. Eck, N. D. Perkins, D. P. Carr, and G. J. Nabel, “Inhibition of phorbol ester-induced cellular adhesion by competitive binding of NF-κB in vivo,” Molecular and Cellular Biology, vol. 13, no. 10, pp. 6530–6536, 1993. View at Google Scholar · View at Scopus
  21. W.-C. Lai, M. Zhou, U. Shankavaram, G. Peng, and L. M. Wahl, “Differential regulation of lipopolysaccharide-induced monocyte matrix metalloproteinase (MMP)-1 and MMP-9 by p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases,” The Journal of Immunology, vol. 170, no. 12, pp. 6244–6249, 2003. View at Google Scholar · View at Scopus
  22. M. P. Vincenti, C. I. Coon, and C. E. Brinckerhoff, “Nuclear factor kappaB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1beta-stimulated synovial fibroblasts,” Arthritis & Rheumatism, vol. 41, pp. 1987–1994, 1998. View at Google Scholar
  23. M. G. Ruocco and M. Karin, “IKKβ as a target for treatment of inflammation induced bone loss,” Annals of the Rheumatic Diseases, vol. 64, supplement 4, pp. iv81–iv85, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. L. A. B. Joosten, M. M. A. Helsen, F. A. J. van de Loo, and W. B. van den Berg, “Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice: a comparative study using anti-TNFα, anti-IL-1α/β, and IL-1Ra,” Arthritis & Rheumatism, vol. 39, no. 5, pp. 797–809, 1996. View at Google Scholar · View at Scopus
  25. P. P. Tak and B. Bresnihan, “The pathogenesis and prevention of joint damage in rheumatoid arthritis: advances from synovial biopsy and tissue analysis,” Arthritis & Rheumatism, vol. 43, pp. 2619–2633, 2000. View at Google Scholar