Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2014, Article ID 196598, 14 pages
http://dx.doi.org/10.1155/2014/196598
Research Article

Protective Effect of Baccharis trimera Extract on Acute Hepatic Injury in a Model of Inflammation Induced by Acetaminophen

1Programa de Pós-graduação em Ciências Biológicas do Núcleo de Pesquisas em Ciências Biológicas (NUPEB), Universidade Federal de Ouro Preto (UFOP), 35.400-000 Ouro Preto, MG, Brazil
2Centro Federal de Educação Tecnológica de Minas Gerais (CEFET/MG), 35.790-970 Curvelo, MG, Brazil
3Departamento de Ciências Biológicas (DECBI), Instituto de Ciências Exatas e Biológicas, Universidade Federal de Ouro Preto (UFOP), 35.400-000 Ouro Preto, MG, Brazil
4Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Cx. Postal 486, 30.161-970 Belo Horizonte, MG, Brazil
5Departamento de Alimentos, Escola de Nutrição, Universidade Federal de Ouro Preto (UFOP), 35.400-000 Ouro Preto, MG, Brazil
6Programa de Pós-graduação em Ciências Farmacêuticas (CIPHARMA), Escola de Farmácia, Universidade Federal de Ouro Preto (UFOP), 35.400-000 Ouro Preto, MG, Brazil
7Núcleo de Pesquisas em Produtos Naturais e Sintéticos, Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirao Preto, Universidade de São Paulo (USP), 14040-903 São Paulo, SP, Brazil

Received 7 July 2014; Revised 13 September 2014; Accepted 8 October 2014; Published 12 November 2014

Academic Editor: Muzamil Ahmad

Copyright © 2014 Bruno da Cruz Pádua et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Acetaminophen (APAP) is a commonly used analgesic and antipyretic. When administered in high doses, APAP is a clinical problem in the US and Europe, often resulting in severe liver injury and potentially acute liver failure. Studies have demonstrated that antioxidants and anti-inflammatory agents effectively protect against the acute hepatotoxicity induced by APAP overdose. Methods. The present study attempted to investigate the protective effect of B. trimera against APAP-induced hepatic damage in rats. The liver-function markers ALT and AST, biomarkers of oxidative stress, antioxidant parameters, and histopathological changes were examined. Results. The pretreatment with B. trimera attenuated serum activities of ALT and AST that were enhanced by administration of APAP. Furthermore, pretreatment with the extract decreases the activity of the enzyme SOD and increases the activity of catalase and the concentration of total glutathione. Histopathological analysis confirmed the alleviation of liver damage and reduced lesions caused by APAP. Conclusions. The hepatoprotective action of B. trimera extract may rely on its effect on reducing the oxidative stress caused by APAP-induced hepatic damage in a rat model. General Significance. These results make the extract of B. trimera a potential candidate drug capable of protecting the liver against damage caused by APAP overdose.