Protective Effect of Baccharis trimera Extract on Acute Hepatic Injury in a Model of Inflammation Induced by Acetaminophen

Figure 9

A schematic diagram showing the protective effect of B. trimera in acetaminophen-induced toxicity. APAP causes excessive oxidative stress and decreases the activity of antioxidant enzymes, such as GR, GPx, and CAT, and increases the activity of SOD, presumably resulting in the elevation of H₂O₂. The disturbance of the oxidant/antioxidant balance causes oxidative stress of the cellular system and results in hepatic injury, specifically the elevation of the ALT and AST. The administration of B. trimera was found to maintain the oxidant/antioxidant balance during APAP treatment, resulting in the prevention of cell damage.