Circulating Biomarkers of Immune Activation Distinguish Viral Suppression from Nonsuppression in HAART-Treated Patients with Advanced HIV-1 Subtype C Infection
Table 2
Most significant correlations in the HIV-infected pre-HAART group [] (paired values represent the correlation coefficients with the corresponding values in parentheses).
VL
TNF-R1
sCD14
CXCL9
IL-6
IL-10
IFN-
CXCL10
CCL2
CCL3
CCL4
TNF-
CRP
2M
CD4
−0.45 (0.05)
−0.52 (0.02)
−0.25 (0.28)
−0.04 (0.88)
−0.32 (0.17)
−0.27 (0.25)
−0.23 (0.33)
−0.18 (0.45)
−0.59 (0.01)
−0.28 (0.23)
−0.30 (0.20)
−0.13 (0.57)
−0.42 (0.07)
−0.30 (0.20)
VL
1.00
0.27 (0.25)
0.58 (0.01)
0.25 (0.28)
0.37 (0.10)
0.07 (0.78)
0.20 (0.40)
0.40 (0.08)
0.36 (0.12)
0.29 (0.22)
0.29 (0.21)
−0.06 (0.79)
0.22 (0.35)
0.64 (0.00)
IFN-
0.31 (0.18)
0.33 (0.16)
0.58 (0.01)
0.31 (0.18)
0.58 (0.01)
0.26 (0.27)
0.44 (0.05)
0.14 (0.56)
0.20 (0.40)
0.66 (0.00)
−0.07 (0.77)
0.45 (0.05)
0.19 (0.42)
0.30 (0.20)
TNF-R1
0.27 (0.25)
1.00
0.58 (0.01)
0.06 (0.79)
0.46 (0.04)
0.29 (0.21)
0.06 (0.79)
0.04 (0.88)
0.03 (0.90)
0.25 (0.29)
−0.03 (0.90)
−0.05 (0.88)
0.54 (0.01)
0.39 (0.09)
sCD14
0.58 (0.01)
0.58 (0.01)
1.00
0.45 (0.05)
0.80 (0.00)
0.19 (0.43)
0.43 (0.06)
0.37 (0.10)
0.11 (0.60)
0.63 (0.00)
0.19 (0.44)
0.26 (0.28)
0.44 (0.05)
0.62 (0.00)
CXCL9
0.25 (0.28)
0.06 (0.79)
0.45 (0.05)
1.00
0.50 (0.02)
0.21 (0.37)
0.64 (0.00)
0.68 (0.00)
0.19 (0.41)
0.64 (0.00)
0.17 (0.46)
0.48 (0.03)
0.25 (0.30)
0.67 (0.00)
IL-6
0.37 (0.10)
0.46 (0.04)
0.80 (0.00)
0.50 (0.02)
1.00
0.50 (0.03)
0.74 (0.00)
0.41 (0.08)
0.37 (0.11)
0.83 (0.00)
0.36 (0.11)
0.57 (0.01)
0.38 (0.10)
0.42 (0.06)
IL-10
0.07 (0.78)
0.19 (0.21)
0.19 (0.43)
0.21 (0.37)
0.50 (0.03)
1.00
0.50 (0.03)
0.20 (0.41)
0.34 (0.14)
0.66 (0.00)
0.43 (0.06)
0.39 (0.09)
−0.12 (0.62)
0.16 (0.49)
IFN-
0.20 (0.40)
0.06 (0.79)
0.43 (0.06)
0.64 (0.00)
0.74 (0.00)
0.50 (0.03)
1.00
0.68 (0.00)
0.60 (0.01)
0.79 (0.00)
0.42 (0.06)
0.64 (0.00)
0.06 (0.80)
0.35 (0.13)
CXCL10
0.40 (0.08)
0.04 (0.88)
0.37 (0.10)
0.68 (0.00)
0.41 (0.08)
0.20 (0.41)
0.68 (0.00)
1.00
0.36 (0.12)
0.48 (0.03)
0.37 (0.11)
0.37 (0.11)
0.25 (0.30)
0.60 (0.05)
CCL2
0.36 (0.12)
0.03 (0.90)
0.11 (0.63)
0.19 (0.41)
0.37 (0.11)
0.34 (0.14)
0.60 (0.01)
0.36 (0.12)
1.00
0.48 (0.03)
0.58 (0.01)
0.28 (0.23)
0.04 (0.89)
0.22 (0.35)
CCL3
0.29 (0.22)
0.25 (0.29)
0.63 (0.00)
0.64 (0.00)
0.83 (0.00)
0.66 (0.00)
0.79 (0.00)
0.48 (0.03)
0.48 (0.03)
1.00
0.41 (0.07)
0.64 (0.00)
0.12 (0.61)
0.44 (0.05)
Spearman correlation test; statistically significant correlations () are shown in bold.
