Mediators of Inflammation / 2014 / Article / Fig 4

Research Article

YKL-40 as a Novel Factor Associated with Inflammation and Catabolic Mechanisms in Osteoarthritic Joints

Figure 4

Relation of YKL-40 to proinflammatory cytokines IL-6 and IL-7. In synovial fluid, YKL-40 correlated positively with (a) IL-6 and (b) IL-17 ( , and , , resp.). In the case of IL-17, the levels were measured from SF samples from 47 patients but the levels remained below the detection limit in about half of the patients ( ) and they were excluded from the correlation analysis. (c) In a 24 h incubation IL-6 together with its soluble receptor (sIL-6R) and IL-17 stimulated YKL-40 production by over 30% in primary chondrocytes from OA cartilage. Results are presented as mean ± SEM. compared to the control sample.