Secretoglobin Superfamily Protein SCGB3A2 Deficiency Potentiates Ovalbumin-Induced Allergic Pulmonary Inflammation
Figure 3
OVA-induced airway inflammation. ((a) and (b)) Representative lung H&E stained sections of OVA inhalation challenged and (+/+) mice (a), and and (+/+) mice (b). There is mild peribronchiolar and perivascular cuffing with inflammatory cells. Magnification 400x. ((c) and (d)) Degree of OVA-induced airway inflammation was determined using inflammatory grade, bronchiolar mucus production, infiltrating eosinophils, and perivascular and peribronchiolar cuffing as described in Section 2 for and (+/+) mice (c), and and (+/+) mice (d). ((e) and (f)) Analysis of BALF inflammatory cell numbers from and (+/+) mice with OVA challenge (OVA) as compared with saline challenge (Saline) (e), and and (+/+) mice with OVA challenge (OVA) as compared with saline challenge (Saline) (f). and by Student’s t-test for (c) and (d) and one-way ANOVA for (e) and (f).
