Paraoxonase1 Genetic Polymorphisms in a Mixed Ancestry African Population
Table 1
Genotype distributions, minor allele frequencies, and unadjusted values for comparing genotype distributions according to diabetes status, and additive allelic effects between diabetes groups.
Without diabetes
Diabetes
Overall
Men
Women
606
238
844
208
636
PON1 rs662
QQ192, (%)
97 (16.0)
36 (15.1)
0.028
133 (15.8)
32 (15.4)
101 (15.9)
0.722
Q192R, (%)
272 (44.9)
130 (54.6)
402 (47.6)
104 (50.0)
298 (46.9)
192RR, (%)
237 (39.1)
72 (30.3)
309 (36.6)
72 (34.6)
237 (37.3)
Q, (%)
466 (38.4)
202 (42.4)
668 (39.6)
168 (40.4)
500 (39.3)
R, (%)
746 (61.6)
274 (57.6)
1020 (60.4)
248 (59.6)
772 (60.7)
HWE ( value)
0.199
0.085
0.943
0.666
0.678
PON1 rs854560
55MM, (%)
420 (69.3)
156 (65.6)
0.168
576 (68.3)
152 (73.1)
424 (66.7)
0.066
L55M, (%)
172 (28.4)
71 (29.8)
243 (28.8)
54 (26.0)
189 (29.7)
LL55, (%)
14 (2.3)
11 (4.6)
25 (3.0)
2 (1.0)
23 (3.62)
L, (%)
200 (16.5)
93 (19.5)
293 (17.4)
58 (13.9)
235 (18.5)
M, (%)
1012 (83.5)
383 (80.5)
1395 (82.6)
358 (86.1)
1037 (81.5)
HWE ( value)
0.556
0.412
>0.999
0.383
0.694
HWE: Hardy-Weinberg Equilibrium (HWE values are from exact tests).
