Paraoxonase1 Genetic Polymorphisms in a Mixed Ancestry African Population

Table 3

Associations of genotypes with PON1 and oxidative stress markers.

Characteristics	PON1 rs662				PON1 rs854560				Overall
	QQ192	Q192R	192RR	value	55MM	L55M	LL55	value
	53 (14.3)	191 (51.6)	126 (34.1)		246 (66.5)	114 (30.8)	10 (2.7)		370
Men, (%)	12 (22.6)	49 (25.7)	33 (26.2)	0.878	66 (26.8)	27 (23.7)	1 (10)	0.429	94
Diabetes, (%)	17 (32.1)	67 (35.1)	28 (22.2)	0.049	71 (28.9)	36 (31.6)	5 (50.0)	0.338	112
Hypertension, (%)	31 (58.5)	100 (52.4)	56 (44.4)	0.177	124 (50.4)	56 (49.1)	7 (70.0)	0.447	187
PON1 conc (µg/mL)	104 [94–117]	101 [78–112]	94 [71–111]	0.015	98 [74–113]	98 [81–111]	105 [95–112]	0.429	98 [77–112]
PONase (U/L)	130 [93–182]	189 [146–222]	185 [144–222]	<0.0001	183 [132–222]	185 [132–220]	119 [96–160]	0.059	183 [130–220]
AREase (kU/L)	97 [72–119]	108 [85–133]	108 [84–132]	0.346	104 [82–132]	108 [83–133]	125 [120–137]	0.252	108 [83–132]
FRAP (µM)	651 [526–754]	702 [541–832]	677 [559–831]	0.381	677 [543–840]	677 [547–763]	674 [567–755]	0.827	677 [545–817]
TEAC (nM)	1206 [837–1442]	1298 [946–1632]	1338 [971–1644]	0.053	1299 [934–1645]	1268 [945–1581]	1303 [1237–1330]	0.774	1289 [941–1626]
Ox-LDL (ng/mL)	3791 [2227–6155]	4695 [3361–6009]	4142 [2972–5298]	0.029	4281 [3184–5622]	4602 [3049–5842]	2682 [1463–6314]	0.501	4284 [3082–5719]
TBARS (nM)	1840 [942–3042]	2424 [1844–3148]	2223 [1598–2978]	0.006	2298 [1640–3128]	2282 [1625–3042]	1114 [950–2822]	0.221	2282 [1622–3116]

PON1: Paraoxonase 1; PONase: paraoxonase activity; AREase: arylesterase activity; FRAP: ferric reducing ability of plasma; TEAC: Trolox equivalent antioxidant capacity; Ox-LDL: oxidized LDL; TBARS: thiobarbituric acid reactive substances.