Paraoxonase1 Genetic Polymorphisms in a Mixed Ancestry African Population

Table 4

Regression coefficients from multiple robust linear models for the prediction of indices of PON1 and antioxidant status by PON1 polymorphisms, accounting for the potential effect of sex, age, diabetes, and adiposity.

Gene	Model	PON1		PONase		AREase		FRAP		TEAC		Ox-LDL		TBARS
		PON1 Q192 (rs662)	Alone	6.84	0.002	−18.33	0.002	−3.11	0.266	−15.68	0.299	−74.92	0.061	39.21	0.804	−42.38	0.621
+ Age	6.18		0.006	−18.31	0.001	−2.92	0.312	−14.98	0.328	−68.15	0.096	34.14	0.814	−79.42	0.346
+ sex	5.61		0.003	−17.99	0.0006	−3.44	0.166	−14.41	0.346	−66.78	0.080	41.48	0.777	−83.18	0.393
+ BMI	5.38		0.008	−15.74	0.0009	−2.42	0.339	−10.41	0.471	−64.51	0.075	−54.69	0.711	−100.98	0.211
+ Diabetes	5.82		0.001	−15.41	0.002	−0.77	0.759	−9.54	0.485	−51.33	0.121	−142.46	0.348	−109.75	0.152
+ DiabetesQ192R	3.79		0.08	−14.99	0.007	−2.94	0.291	−14.50	0.359	−40.30	0.340	−155.24	0.354	−87.90	0.321
DiabetesQ192		11.32	0.007	2.09	0.848	4.85	0.366	22.86	0.472	−49.17	0.553	122.96	0.709	−138.59	0.438
PON1 L55 (rs854560)	Alone	1.76	0.518	−5.37	0.455	3.17	0.361	−21.31	0.274	−31.05	0.534	−184.80	0.314	−64.68	0.529
	+ Age	0.82	0.758	−5.39	0.461	3.22	0.376	−21.36	0.277	−30.42	0.541	−183.27	0.322	−91.05	0.355
	+ sex	1.05	0.508	−6.62	0.338	2.49	0.474	−19.21	0.354	−29.75	0.528	−156.72	0.380	−93.82	0.327
	+ BMI	2.65	0.235	−5.86	0.340	5.10	0.155	−11.71	0.523	−18.32	0.687	−220.02	0.222	−104.31	0.303
	+ Diabetes	2.77	0.217	−6.36	0.277	5.00	0.104	−12.95	0.492	−9.50	0.825	−256.49	0.154	−106.93	0.261
	+ DiabetesL55M	3.03	0.278	−5.88	0.467	5.99	0.109	−24.85	0.240	−17.61	0.745	−395.49	0.075	−222.50	0.062
DiabetesL55		−0.69	0.883	−5.58	0.682	−10.34	0.119	41.03	0.266	21.27	0.775	994.86	0.013	391.84	0.058
PON1 Q192 (rs662)	PON1 L55	7.13	0.002	−18.34	0.002	−4.01	0.158	−13.00	0.418	−73.65	0.077	77.21	0.635	−32.88	0.716
	+ Q192L55	7.83	0.005	−15.89	0.018	−2.77	0.403	−19.55	0.297	−81.54	0.092	169.29	0.350	−44.91	0.683
PON1 L55 (rs854560)	PON1 Q192	−1.02	0.705	−0.05	0.994	4.42	0.215	−17.81	0.379	−6.39	0.902	−212.36	0.304	−57.23	0.615
	+ Q192L55	2.88	0.544	11.71	0.377	8.47	0.183	−37.88	0.287	−31.84	0.728	65.66	0.849	−98.36	0.638
Q192L55		−3.30	0.435	−10.16	0.339	−3.93	0.449	22.32	0.449	25.11	0.737	−282.13	0.326	40.08	0.818

BMI: body mass index; PON1: Paraoxonase 1; PONase: paraoxonase activity; AREase: arylesterase activity; FRAP: ferric reducing ability of plasma; TEAC: Trolox equivalent antioxidant capacity; Ox-LDL: oxidized LDL; TBARS: thiobarbituric acid reactive substances.