Mediators of Inflammation / 2014 / Article / Tab 4 / Research Article
Paraoxonase1 Genetic Polymorphisms in a Mixed Ancestry African Population Table 4 Regression coefficients from multiple robust linear models for the prediction of indices of PON1 and antioxidant status by PON1 polymorphisms, accounting for the potential effect of sex, age, diabetes, and adiposity.
Gene Model PON1 PONase AREase FRAP TEAC Ox-LDL TBARS PON1 Q192 (rs662) Alone 6.84 0.002 −18.33 0.002 −3.11 0.266 −15.68 0.299 −74.92 0.061 39.21 0.804 −42.38 0.621 + Age 6.18 0.006 −18.31 0.001 −2.92 0.312 −14.98 0.328 −68.15 0.096 34.14 0.814 −79.42 0.346 + sex 5.61 0.003 −17.99 0.0006 −3.44 0.166 −14.41 0.346 −66.78 0.080 41.48 0.777 −83.18 0.393 + BMI 5.38 0.008 −15.74 0.0009 −2.42 0.339 −10.41 0.471 −64.51 0.075 −54.69 0.711 −100.98 0.211 + Diabetes 5.82 0.001 −15.41 0.002 −0.77 0.759 −9.54 0.485 −51.33 0.121 −142.46 0.348 −109.75 0.152 + Diabetes Q192R 3.79 0.08 −14.99 0.007 −2.94 0.291 −14.50 0.359 −40.30 0.340 −155.24 0.354 −87.90 0.321 Diabetes Q192 11.32 0.007 2.09 0.848 4.85 0.366 22.86 0.472 −49.17 0.553 122.96 0.709 −138.59 0.438 PON1 L55 (rs854560) Alone 1.76 0.518 −5.37 0.455 3.17 0.361 −21.31 0.274 −31.05 0.534 −184.80 0.314 −64.68 0.529 + Age 0.82 0.758 −5.39 0.461 3.22 0.376 −21.36 0.277 −30.42 0.541 −183.27 0.322 −91.05 0.355 + sex 1.05 0.508 −6.62 0.338 2.49 0.474 −19.21 0.354 −29.75 0.528 −156.72 0.380 −93.82 0.327 + BMI 2.65 0.235 −5.86 0.340 5.10 0.155 −11.71 0.523 −18.32 0.687 −220.02 0.222 −104.31 0.303 + Diabetes 2.77 0.217 −6.36 0.277 5.00 0.104 −12.95 0.492 −9.50 0.825 −256.49 0.154 −106.93 0.261 + Diabetes L55M 3.03 0.278 −5.88 0.467 5.99 0.109 −24.85 0.240 −17.61 0.745 −395.49 0.075 −222.50 0.062 Diabetes L55 −0.69 0.883 −5.58 0.682 −10.34 0.119 41.03 0.266 21.27 0.775 994.86 0.013 391.84 0.058 PON1 Q192 (rs662) PON1 L55 7.13 0.002 −18.34 0.002 −4.01 0.158 −13.00 0.418 −73.65 0.077 77.21 0.635 −32.88 0.716 + Q192 L55 7.83 0.005 −15.89 0.018 −2.77 0.403 −19.55 0.297 −81.54 0.092 169.29 0.350 −44.91 0.683 PON1 L55 (rs854560) PON1 Q192 −1.02 0.705 −0.05 0.994 4.42 0.215 −17.81 0.379 −6.39 0.902 −212.36 0.304 −57.23 0.615 + Q192 L55 2.88 0.544 11.71 0.377 8.47 0.183 −37.88 0.287 −31.84 0.728 65.66 0.849 −98.36 0.638 Q192 L55 −3.30 0.435 −10.16 0.339 −3.93 0.449 22.32 0.449 25.11 0.737 −282.13 0.326 40.08 0.818
BMI: body mass index; PON1: Paraoxonase 1; PONase: paraoxonase activity; AREase: arylesterase activity; FRAP: ferric reducing ability of plasma; TEAC: Trolox equivalent antioxidant capacity; Ox-LDL: oxidized LDL; TBARS: thiobarbituric acid reactive substances.